大肠杆菌DNA促旋酶A基因中的突变扩展了喹诺酮耐药决定区。
Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.
作者信息
Friedman S M, Lu T, Drlica K
机构信息
Department of Biological Sciences, Hunter College of The City University of New York, New York, New York 10021, USA.
出版信息
Antimicrob Agents Chemother. 2001 Aug;45(8):2378-80. doi: 10.1128/AAC.45.8.2378-2380.2001.
Abstract
In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.
摘要
在三个大肠杆菌突变体中，位于标准喹诺酮耐药决定区（QRDR）之外的gyrase A蛋白中的一个变化（丙氨酸-51变为缬氨酸）比氨基酸67、82、84和106处的变化更能降低喹诺酮的敏感性水平。表明应修订QRDR以纳入氨基酸51。
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