Ghilardi J R, Allen C J, Vigna S R, McVey D C, Mantyh P W
Molecular Neurobiology Laboratory (151), Veterans Administration Medical Center, Minneapolis, MN 55417.
Brain Res. 1994 Jan 7;633(1-2):33-40. doi: 10.1016/0006-8993(94)91519-9.
A [125I]cholecystokinin (CCK) analog and [125I]peptide YY (PYY) were used to localize and characterize CCK and neuropeptide Y (NPY) receptor binding sites in the rabbit vagal afferent (nodose) ganglion. High concentrations of CCK and NPY binding sites were observed in 10.6% and 9.2% of the nodose ganglion neurons, respectively. Pharmacological experiments using CCK or NPY analogs suggest that both subtypes of CCK (CCK-A and CCK-B) and NPY (Y1 and Y2) receptor binding sites are expressed by discrete populations of neurons in the nodose ganglion. These results suggest sites at which CCK or NPY, released in either the nucleus of the solitary tract or a peripheral tissue, may modulate the release of neurotransmitters from a select population of visceral primary afferent neurons. Possible functions mediated by these receptors include modulation of satiety, opiate analgesia, and the development of morphine tolerance.
一种[125I]胆囊收缩素（CCK）类似物和[125I]肽YY（PYY）被用于定位和表征兔迷走传入（结状）神经节中的CCK和神经肽Y（NPY）受体结合位点。分别在10.6%和9.2%的结状神经节神经元中观察到高浓度的CCK和NPY结合位点。使用CCK或NPY类似物的药理学实验表明，CCK的两种亚型（CCK-A和CCK-B）和NPY的两种亚型（Y1和Y2）受体结合位点均由结状神经节中不同的神经元群体表达。这些结果表明，在孤束核或外周组织中释放的CCK或NPY可能在这些位点调节来自特定内脏初级传入神经元群体的神经递质释放。这些受体介导的可能功能包括饱腹感调节、阿片类镇痛以及吗啡耐受性的形成。
