c-myc mRNA的表达有助于胃腺瘤与高分化腺癌的组织学鉴别。
Expression of c-myc mRNA as an aid in histologic differentiation of adenoma from well differentiated adenocarcinoma in the stomach.
作者信息
Tatsuta M, Iishi H, Baba M, Nakaizumi A, Uehara H, Taniguchi H
机构信息
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
出版信息
Cancer. 1994 Apr 1;73(7):1795-9. doi: 10.1002/1097-0142(19940401)73:7<1795::aid-cncr2820730704>3.0.co;2-x.
BACKGROUND
Using prospective follow-up studies, the authors examined the value of the expression of c-myc mRNA in biopsy specimens obtained from elevated gastric lesions as an aid in the differentiating between adenomas and well differentiated elevated-type adenocarcinomas.
METHODS
By in situ hybridization, the authors determined the expression of c-myc mRNA in biopsy specimens of elevated gastric lesions. The 31 patients who had borderline lesions with and without overexpression of c-myc were followed with repeated endoscopic examinations and gastric biopsies.
RESULTS
Endoscopic follow-up examinations showed that gastric cancer was detected in 5 of 11 patients (46%) with elevated lesions that stained positively for c-myc mRNA during an observation period of 15 months (range, 2-32 months). The cancers were confirmed histologically in gastrectomy specimens. No cancers were found in patients with elevated lesions that stained negatively. The difference was statistically significant (P < 0.01).
CONCLUSIONS
The overexpression of c-myc mRNA may present a new tool for distinguishing between adenomas and well differentiated adenocarcinomas of the elevated type.
背景
通过前瞻性随访研究，作者检测了取自胃隆起性病变活检标本中c-myc mRNA的表达情况，以辅助鉴别腺瘤与高分化隆起型腺癌。
方法
作者通过原位杂交法测定胃隆起性病变活检标本中c-myc mRNA的表达。对31例c-myc有或无过表达的临界病变患者进行重复内镜检查及胃活检随访。
结果
内镜随访检查显示，在15个月（范围2 - 32个月）的观察期内，11例c-myc mRNA染色阳性的隆起性病变患者中有5例（46%）检测到胃癌，胃癌在胃切除标本中经组织学证实。c-myc mRNA染色阴性的隆起性病变患者未发现癌症。差异具有统计学意义（P < 0.01）。
结论
c-myc mRNA的过表达可能为鉴别隆起型腺瘤与高分化腺癌提供一种新工具。
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