通过比较基因组杂交技术对原发性小细胞肺癌中多个DNA片段的增减进行图谱绘制。
Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization.
作者信息
Ried T, Petersen I, Holtgreve-Grez H, Speicher M R, Schröck E, du Manoir S, Cremer T
机构信息
Institute of Human Genetics, University of Heidelberg, Germany.
出版信息
Cancer Res. 1994 Apr 1;54(7):1801-6.
Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens. The most abundant genetic changes include DNA losses of chromosome arms 3p, 5q, 10q, 13q, and 17p and DNA gains of 3q, 5p, 8q, and 17q. Amplification sites in these tumors were mapped to 22 chromosome bands. The most frequently involved band was 19q13.1 (4 cases). Bands 1p32, 2p23, 7q11.2, 8q24, and 13q33-34 were involved in two cases each.
采用比较基因组杂交技术对13例小细胞肺癌尸检标本中的遗传物质缺失和扩增情况进行全面筛查。最常见的基因改变包括3p、5q、10q、13q和17p染色体臂的DNA缺失以及3q、5p、8q和17q的DNA增益。这些肿瘤中的扩增位点定位于22个染色体带。最常涉及的带是19q13.1（4例）。1p32、2p23、7q11.2、8q24和13q33 - 34带各有2例涉及。
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