金盐对肿瘤免疫的影响及其受短小棒状杆菌的刺激作用。
The effect of gold salts on tumour immunity and its stimulation by Corynebacterium Parvum.
作者信息
McBride W H, Tuach S, Marmion B P
出版信息
Br J Cancer. 1975 Nov;32(5):558-67. doi: 10.1038/bjc.1975.261.
The anti-inflammatory agent sodium aurothiomalate appears to act upon mononuclear phagocytes, inhibiting their lysosomal enzyme activity. Evidence is presented that gold salts can increase the number of lung tumour nodules that develop following intravenous injection of tumour cells and pretreatment can enhance the take of a subcutaneous tumour inoculum. In contrast, they do not affect the later growth of tumour. Gold salts can also suppress the action of systemically administered C. parvum in inhibiting the growth of subcutaneous tumours. These results are taken as supporting the evidence in favour of a fast acting nonspecific anti-tumour mechanism, probably macrophage mediated, that can be inhibited by gold salts and enhanced by C. parvum. The effect of gold salts upon other biological changes induced by C. parvum is examined, including its adjuvant action, and the results are discussed in the context of the mechanisms underlying the immunotherapeutic action of this organism.
抗炎剂硫代苹果酸金钠似乎作用于单核吞噬细胞，抑制其溶酶体酶活性。有证据表明，金盐可增加静脉注射肿瘤细胞后形成的肺肿瘤结节数量，且预处理可增强皮下肿瘤接种物的接种成功率。相比之下，它们并不影响肿瘤后期的生长。金盐还可抑制全身给药的微小隐孢子虫对皮下肿瘤生长的抑制作用。这些结果被视为支持以下证据：存在一种可能由巨噬细胞介导的快速起效的非特异性抗肿瘤机制，该机制可被金盐抑制，而被微小隐孢子虫增强。研究了金盐对微小隐孢子虫诱导的其他生物学变化的影响，包括其佐剂作用，并在该生物体免疫治疗作用的潜在机制背景下对结果进行了讨论。
Zotero 插件