Liu Y G
Department of Biochemistry Qinghai Medical College, Xi'ning.
Zhonghua Yu Fang Yi Xue Za Zhi. 1993 Sep;27(5):294-5.
The activities of CuZn-SOD and Mn-SOD in rat plasma and liver dropped (P < 0.05 and P < 0.01, respectively) but LPO levels increased significantly (P < 0.01) after the rats were got into plateau from plain rapidly. The decrease of the activities of SODs was associated with the rise of LPO levels. The results suggested that the formation of free radicals in the body increased and the antioxidant ability lowered after their rapid entry into plateau from plain, and it was unfavourable to their acclimatization to plateau.
大鼠从平原快速进入高原后，其血浆和肝脏中铜锌超氧化物歧化酶（CuZn-SOD）和锰超氧化物歧化酶（Mn-SOD）的活性下降（分别为P < 0.05和P < 0.01），但脂质过氧化（LPO）水平显著升高（P < 0.01）。超氧化物歧化酶活性的降低与LPO水平的升高相关。结果表明，大鼠从平原快速进入高原后，体内自由基生成增加，抗氧化能力降低，这不利于它们对高原环境的适应。
