Watson A, Vandekerckhove P, Lilford R, Vail A, Brosens I, Hughes E
Institute of Epidemiology and Health Services Research, University of Leeds, United Kingdom.
Fertil Steril. 1994 Mar;61(3):470-7. doi: 10.1016/s0015-0282(16)56578-9.
To evaluate the therapeutic effect of oil-soluble contrast media compared with water-soluble contrast media after hysterosalpingography (HSG) in infertile couples.
Meta-analysis of four randomized clinical trials (RCTs) and six nonrandomized controlled studies evaluating pregnancy rates after the use of oil- or water-soluble contrast media during HSG.
Institute of Epidemiology and Health Services Research, Leeds, United Kingdom.
Four identified RCTs studied 800 patients and six nonrandomized studies comprised an additional 1,806 patients, all experiencing primary or secondary infertility.
Hysterosalpingography as part of infertility investigation.
Pregnancy rates after HSG.
Pregnancy rates were significantly higher in the oil-soluble contrast media group compared with the water-soluble contrast media group in the RCTs. Inclusion of the six nonrandomized studies did not alter this conclusion. This apparent benefit was greatest for patients with unexplained infertility.
Oil-soluble contrast media have a therapeutic effect compared with water-soluble media and this effect is greatest for patients who have been diagnosed as having unexplained infertility. New techniques for the evaluation of tubal patency support the hypothesis that tubal "plugs" may be involved in proximal tubal blockage.
评估子宫输卵管造影术（HSG）后，油溶性造影剂与水溶性造影剂相比，对不孕夫妇的治疗效果。
对四项随机临床试验（RCT）和六项非随机对照研究进行荟萃分析，评估HSG期间使用油溶性或水溶性造影剂后的妊娠率。
英国利兹市流行病学与卫生服务研究所。
四项已确定的RCT研究了800名患者，六项非随机研究另外纳入了1806名患者，所有患者均患有原发性或继发性不孕症。
子宫输卵管造影术作为不孕症检查的一部分。
HSG后的妊娠率。
在RCT中，油溶性造影剂组的妊娠率显著高于水溶性造影剂组。纳入六项非随机研究并未改变这一结论。这种明显的益处对于不明原因不孕症患者最为显著。
与水溶性造影剂相比，油溶性造影剂具有治疗效果，且这种效果对于被诊断为不明原因不孕症的患者最为显著。输卵管通畅性评估的新技术支持输卵管“堵塞物”可能与近端输卵管阻塞有关的假说。
