银屑病患者人体红细胞的能量代谢

Energy metabolism of human erythrocytes in psoriasis.

Goncharenko M S, Kosenko E A, Kaminsky Y G

Department of Public Health of Ukraine, Research Institute of Dermatology and Venerology, Russia.

Int J Biochem. 1993 Dec;25(12):1905-8. doi: 10.1016/0020-711x(88)90323-0.

Abstract

Adenine nucleotide concentrations and metabolism in red blood cells (RBC) and RBC ghosts from psoriatic patients and healthy subjects were compared. 2. The ATP and total adenine nucleotide levels and the adenylate energy charge (EC) were elevated in the blood from psoriatic patients. 3. The rate of glycolytic production of ATP by intact RBC was unchanged, but the Na+, K(+)-ATPase activity of RBC ghosts was decreased significantly in psoriasis. 4. Results suggest that the defect in adenine nucleotide metabolism is a systemic manifestation of psoriasis, and that the quantification of adenine nucleotides in RBC and in whole blood samples may be of pathophysiological value in psoriatic lesion.

摘要

比较了银屑病患者和健康受试者红细胞（RBC）及红细胞血影中腺嘌呤核苷酸的浓度和代谢情况。2. 银屑病患者血液中的ATP、总腺嘌呤核苷酸水平及腺苷酸能荷（EC）升高。3. 完整红细胞通过糖酵解产生ATP的速率未变，但银屑病患者红细胞血影的钠钾ATP酶活性显著降低。4. 结果表明，腺嘌呤核苷酸代谢缺陷是银屑病的一种全身表现，红细胞和全血样本中腺嘌呤核苷酸的定量对银屑病皮损可能具有病理生理学价值。