[Adenine nucleotides and adenylate anergy charge in erythrocytes in psoriasis].

Concentration of ATP, total content of adenine nucleotides and energy charge of the adenylate system were distinctly higher in blood of patients with psoriasis as compared with corresponding patterns of healthy persons blood. In psoriasis the rate of glycolytic production of ATP was unaltered in erythrocytes, whereas Na+, K+-ATPase activity was decreased in the cell membranes. Similar alterations occurred in epidermis impaired with psoriasis. The data obtained suggest the systemic type of the pathological process, which caused impairment of adenine nucleotides metabolism. Estimation of ATP concentration, of total content of adenine nucleotides and adenylate energy charge might be of importance in diagnosis and therapy of psoriasis.