Yoshiba M, Dehara K, Inoue K, Okamoto H, Mayumi M
Department of Medicine, Showa University Fujigaoka Hospital, Yokohama City, Japan.
Hepatology. 1994 Apr;19(4):829-35.
To assess the contribution of hepatitis C virus to non-A, non-B fulminant hepatitis in Japan, we compared 10 major clinical features among 7 patients with type B fulminant hepatitis (type B group), 13 patients with non-A, non-B fulminant hepatitis with evidence of hepatitis C virus infection (type C group) and 10 patients without evidence of hepatitis C virus infection (NANB group). Duration from first symptom to coma and that from onset of jaundice to coma was significantly longer in the type C group (median = 39 and 25 days, respectively) and in the non-A, non-B group (median = 29 and 12 days, respectively) than in the type B group (median = 9 and 2 days, respectively) (p < 0.01). The maximum median AST level was significantly lower in the type C (1,689 U/L) and non-A, non-B groups (1,353 U/L) than in the type B group (5,780 U/L) (p < 0.05). Serum transaminase levels showed a single peak in six of seven of the type B patients, whereas they formed two or more peaks in all of the type C patients and in most of the non-A, non-B group (p < 0.05). Six of seven in the type B group, 6 of 13 in the type C group and 4 of 10 in the non-A, non-B group survived (p < 0.05). We found no significant difference in any of the 10 clinical features between the type C and non-A, non-B groups.(ABSTRACT TRUNCATED AT 250 WORDS)
为评估丙型肝炎病毒对日本非甲非乙型暴发性肝炎的影响，我们比较了7例B型暴发性肝炎患者（B型组）、13例有丙型肝炎病毒感染证据的非甲非乙型暴发性肝炎患者（C型组）和10例无丙型肝炎病毒感染证据的患者（非甲非乙组）的10项主要临床特征。C型组（中位数分别为39天和25天）和非甲非乙组（中位数分别为29天和12天）从首发症状到昏迷以及从黄疸出现到昏迷的持续时间显著长于B型组（中位数分别为9天和2天）（p<0.01）。C型组（1689 U/L）和非甲非乙组（1353 U/L）的最高中位数谷草转氨酶水平显著低于B型组（5780 U/L）（p<0.05）。7例B型患者中有6例血清转氨酶水平呈单峰，而所有C型患者和大多数非甲非乙组患者的血清转氨酶水平形成两个或更多峰（p<0.05）。B型组7例中有6例、C型组13例中有6例、非甲非乙组10例中有4例存活（p<0.05）。我们发现C型组和非甲非乙组在10项临床特征中的任何一项上均无显著差异。（摘要截短于250字）
