Rastogi N, Chag M, Ayyagari S
Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Int J Cardiol. 1993 Dec 31;42(3):285-7. doi: 10.1016/0167-5273(93)90061-k.
A 40-year-old male patient with carcinoma of the tonsil was put on a 5-fluorouracil and cisplatinum regimen. On day 2 during 5-fluorouracil infusion, he had features of myocardial ischemia manifesting as angina and ST-elevation in ECG. These vasospastic ischemic changes subsided after nitroglycerine plus nifedipine therapy. Such vasospastic toxicity of 5-fluorouracil is rare and few such cases have been reported.
一名40岁的扁桃体癌男性患者接受了氟尿嘧啶和顺铂治疗方案。在输注氟尿嘧啶的第2天，他出现了心肌缺血的症状，表现为心绞痛和心电图ST段抬高。经硝酸甘油加硝苯地平治疗后，这些血管痉挛性缺血改变消退。氟尿嘧啶的这种血管痉挛性毒性很罕见，此类病例报道较少。
