Ariaratnam V, Georghiou G P
Bull World Health Organ. 1975;52(1):91-6.
The roles of increased metabolism and reduced penetration as possible mechanisms of resistance to carbaryl were investigated in a strain of A. albimanus from El Salvador in which carbamate and organophosphorus resistance had been induced by laboratory selection with propoxur. Carbaryl was metabolized to N-hydroxymethylcarbaryl, 5,6-dihydro-5,6-dihydroxycarbaryl and an unidentified metabolite A. The rate of metabolism by the resistant strain was only slightly higher than that by the parental strain. The rate of penetration of carbaryl in the parental strain was nearly twice that in the resistant strain during the first hour of exposure. However, this difference did not persist for as long as 90 min. Because of the low level of carbamate metabolism detected, it was concluded that the high resistance of the strain must be due to the action of some as yet unidentified mechanism, possibly enhanced by factors controlling the penetration and metabolism of the toxicant.
在一株来自萨尔瓦多的白纹伊蚊中，研究了代谢增加和穿透减少作为对西维因抗性可能机制的作用。该株白纹伊蚊通过用残杀威进行实验室选育诱导出了对氨基甲酸酯类和有机磷的抗性。西维因被代谢为N-羟甲基西维因、5,6-二氢-5,6-二羟基西维因和一种未鉴定的代谢物A。抗性品系的代谢速率仅略高于亲本品系。在接触的第一小时内，西维因在亲本品系中的穿透速率几乎是抗性品系的两倍。然而，这种差异在90分钟内并未持续存在。由于检测到的氨基甲酸酯代谢水平较低，得出的结论是，该品系的高抗性一定是由于某种尚未确定的机制的作用，可能受到控制毒物穿透和代谢的因素的增强。
