Saijo M, Takimoto M, Takahashi Y
Department of Pediatrics, Nayoro City Hospital.
Kansenshogaku Zasshi. 1994 Jan;68(1):1-7. doi: 10.11150/kansenshogakuzasshi1970.68.1.
We carried out an epidemiological study on lower respiratory tract infections, concerning the respiratory syncytial virus (RSV) infection, in northern Hokkaido, Japan, during the 2-year-study period from April 1991 to March 1993. There were 467 hospitalized patients with lower respiratory tract infections. We examined the presence of RSV antigen in their nasopharyngeal specimens of 456 out of 467 patients (97.6%) by enzyme immunoassay. The diagnosis of Mycoplasma pneumoniae infection was done by the rise of antibody titer, performed with complement fixation method, in the sera of the acute and convalescent phases. There were 133 patients with RSV infection (28.9%), 45 patients with Mycoplasma pneumoniae infection (9.8%) and 7 patients with measles virus infection (1.5%). RSV played an important role in the lower respiratory tract infections in northern Hokkaido, Japan. The epidemic of RSV infection was observed in spring and early winter in 1991 and only in early winter in 1992. The number of patients with RSV infection from April 1991 to March 1992 was greater than that from April 1992 to March 1993. In contrast with RSV infection, the epidemic of Mycoplasma pneumoniae infection was observed in 1992. We speculated that the RSV and Mycoplasma pneumoniae infections might interfere with each other.
1991年4月至1993年3月的两年研究期间，我们在日本北海道北部开展了一项关于下呼吸道感染（涉及呼吸道合胞病毒（RSV）感染）的流行病学研究。有467名下呼吸道感染住院患者。我们通过酶免疫测定法检测了467名患者中456名（97.6%）的鼻咽标本中RSV抗原的存在情况。肺炎支原体感染的诊断是通过在急性期和恢复期血清中采用补体结合法检测抗体滴度升高来进行的。有133名患者感染RSV（28.9%），45名患者感染肺炎支原体（9.8%），7名患者感染麻疹病毒（1.5%）。RSV在日本北海道北部的下呼吸道感染中起重要作用。1991年春季和初冬观察到RSV感染的流行，1992年只在初冬观察到。1991年4月至1992年3月RSV感染患者的数量多于1992年4月至1993年3月。与RSV感染相反，1992年观察到肺炎支原体感染的流行。我们推测RSV感染和肺炎支原体感染可能相互干扰。
