Tian Dan-Dan, Jiang Rong, Chen Xue-Jun, Ye Qing
Clinical Laboratory, The Children´s Hospital of Zhejiang University School of Medicine, Hangzhou, China.
PLoS One. 2017 Mar 10;12(3):e0173409. doi: 10.1371/journal.pone.0173409. eCollection 2017.
Pneumonia is common in children and mostly caused by many pathogens. The aim of this study was to investigate whether the incidence of pediatric mycoplasma pneumoniae (MP) pneumonia and respiratory syncytial virus (RSV) pneumonia was associated with meteorological factors in Hangzhou, China.
A total of 36500 pneumonia patients were recruited to participate in the study. Nasopharyngeal swabs were collected for the detection of MP and RSV using real-time polymerase chain reaction (RT-PCR) and direct immunofluorescence (DIF) assays, respectively. We used a distributed lag non-linear model (DLNM) to evaluate the correlations between the MP/RSV incidence and meteorological factors.
The detection rates of MP and RSV were 18.4% and 10.4%, respectively. There was a positive correlation between temperature and the MP infection rate, but RSV infection rate was negatively associated with temperature. Moreover, the impact of temperature on infection with RSV presented evident lag and cumulative effects. There was also an evident lag effect of temperature on the infection rate of MP; however, there was no evident cumulative effect.
In this study, the results showed meteorological factors play an important role in the incidence of these two pathogens. All these results can provide the laboratory basis for the early diagnosis and treatment of pneumonia in children.
肺炎在儿童中很常见，主要由多种病原体引起。本研究的目的是调查中国杭州儿童支原体肺炎（MP）和呼吸道合胞病毒（RSV）肺炎的发病率是否与气象因素有关。
共招募36500例肺炎患者参与本研究。分别采用实时聚合酶链反应（RT-PCR）和直接免疫荧光（DIF）检测法采集鼻咽拭子，检测MP和RSV。我们使用分布滞后非线性模型（DLNM）来评估MP/RSV发病率与气象因素之间的相关性。
MP和RSV的检出率分别为18.4%和10.4%。温度与MP感染率呈正相关，但RSV感染率与温度呈负相关。此外，温度对RSV感染的影响呈现出明显的滞后和累积效应。温度对MP感染率也有明显的滞后效应；然而，没有明显的累积效应。
在本研究中，结果表明气象因素在这两种病原体的发病率中起重要作用。所有这些结果可为儿童肺炎的早期诊断和治疗提供实验室依据。
