Armellini F, Zamboni M, Castelli S, Robbi R, Mino A, Todesco T, Bergamo-Andreis I A, Bosello O
Institute of Internal Medicine, University of Verona, Italy.
Metabolism. 1994 Mar;43(3):390-5. doi: 10.1016/0026-0495(94)90110-4.
Thirty-six women aged 18 to 52 years with body mass indexes (BMIs) between 27 and 52 were studied. Visceral and subcutaneous fat areas and body fat were evaluated by computerized tomography with a single scan at the IV-V lumbar vertebra level. Glucose, insulin, and C-peptide levels were measured before and after a glucose load. Total and free serum testosterone and 24-hour urinary cortisol excretion were measured. A stepwise multiple regression equation showed the visceral to subcutaneous fat area ratio to be the most powerful predictor for glucose alterations both during fasting and after a glucose load, and showed BMI to be the most powerful predictor for insulin and C-peptide levels. Total serum testosterone, after matching for age and BMI, demonstrates a significant negative correlation with visceral fat area. We conclude that in obese women, as in men, intraabdominal fat negatively correlates with serum testosterone levels.
对36名年龄在18至52岁之间、体重指数（BMI）在27至52之间的女性进行了研究。通过在第四至五腰椎水平进行单次扫描的计算机断层扫描来评估内脏和皮下脂肪面积以及体脂。在葡萄糖负荷前后测量血糖、胰岛素和C肽水平。测量总血清睾酮和游离血清睾酮以及24小时尿皮质醇排泄量。逐步多元回归方程显示，内脏与皮下脂肪面积比是空腹期间和葡萄糖负荷后血糖变化的最有力预测指标，且BMI是胰岛素和C肽水平的最有力预测指标。在对年龄和BMI进行匹配后，总血清睾酮与内脏脂肪面积呈显著负相关。我们得出结论，在肥胖女性中，与男性一样，腹部脂肪与血清睾酮水平呈负相关。
