Zamboni M, Armellini F, Turcato E, de Pergola G, Todesco T, Bissoli L, Bergamo Andreis I A, Bosello O
Institute of Internal Medicine, University of Verona, Italy.
J Intern Med. 1994 Nov;236(5):521-7. doi: 10.1111/j.1365-2796.1994.tb00839.x.
The relationships between visceral fat distribution, steroid hormones and peripheral insulin sensitivity were studied.
All subjects were hospitalized in the Institute of Internal Medicine of the University of Verona, Italy.
Nineteen fertile obese women were studied with ages ranging from 18 to 53 years and body mass indexes ranging from 27.3 to 48.4.
Body fat distribution was evaluated by waist-to-hip circumference ratio and by computed tomography. The insulin tolerance test was used to evaluate peripheral insulin sensitivity. Glucose, insulin and C-peptide were measured in fasting conditions and during glucose load; total and free plasma testosterone and urinary cortisol excretion were also determined.
Significant correlations emerged between visceral adipose tissue and fasting glucose, insulin, and C-peptide, but not between visceral adipose tissue and total testosterone, free testosterone or urinary cortisol excretion. A negative correlation emerged between visceral adipose tissue and insulin sensitivity (r = -0.70; P < 0.01). No significant correlations were found between insulin sensitivity and age, body weight, body mass index, total adipose tissue, subcutaneous adipose tissue or waist-to-hip ratio. Total testosterone correlated with body weight, subcutaneous adipose tissue and total adipose tissue. Free testosterone and urinary cortisol excretion correlated positively with body weight, and negatively with age. No correlation was found between insulin sensitivity and total testosterone, free testosterone or urinary cortisol excretion. The correlation between visceral adipose tissue and insulin sensitivity remained significant even after adjusting for both age and the body mass index.
Our study shows that visceral fat is more closely associated with aberrations of insulin sensitivity than with obesity itself. Total testosterone, free testosterone and urinary cortisol excretion in our subjects do not seem to be associated with such aberrations.
研究内脏脂肪分布、类固醇激素与外周胰岛素敏感性之间的关系。
所有受试者均在意大利维罗纳大学内科研究所住院。
对19名育龄肥胖女性进行了研究，年龄在18至53岁之间，体重指数在27.3至48.4之间。
通过腰臀围比和计算机断层扫描评估身体脂肪分布。采用胰岛素耐量试验评估外周胰岛素敏感性。在空腹状态和葡萄糖负荷期间测量血糖、胰岛素和C肽；还测定了血浆总睾酮和游离睾酮以及尿皮质醇排泄量。
内脏脂肪组织与空腹血糖、胰岛素和C肽之间存在显著相关性，但内脏脂肪组织与总睾酮、游离睾酮或尿皮质醇排泄量之间无显著相关性。内脏脂肪组织与胰岛素敏感性之间呈负相关（r = -0.70；P < 0.01）。胰岛素敏感性与年龄、体重、体重指数、总脂肪组织、皮下脂肪组织或腰臀比之间未发现显著相关性。总睾酮与体重、皮下脂肪组织和总脂肪组织相关。游离睾酮和尿皮质醇排泄量与体重呈正相关，与年龄呈负相关。胰岛素敏感性与总睾酮、游离睾酮或尿皮质醇排泄量之间未发现相关性。即使在调整年龄和体重指数后，内脏脂肪组织与胰岛素敏感性之间的相关性仍然显著。
我们的研究表明，内脏脂肪与胰岛素敏感性异常的关联比与肥胖本身更为密切。我们研究对象的总睾酮、游离睾酮和尿皮质醇排泄量似乎与这种异常无关。
