Potenza M N, Lerner M R
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Naunyn Schmiedebergs Arch Pharmacol. 1994 Jan;349(1):11-9. doi: 10.1007/BF00178200.
The response of a cell line of Xenopus laevis melanophores to serotonin was examined. Serotonin increased intracellular levels of cAMP and induced pigment dispersion in the cells. The responses depended on both the concentration of serotonin applied and on the time for which the cells were exposed to serotonin. Using a recently described, microtiter-plate-based bioassay, a series of serotonin receptor ligands were evaluated as agonists or antagonists at the melanophore serotonin receptor. The pharmacological profile suggests the presence of a receptor which shares some properties with but appears different from other previously described serotonin receptors.
对非洲爪蟾黑素细胞系对血清素的反应进行了研究。血清素增加了细胞内cAMP的水平，并诱导细胞内色素分散。这些反应既取决于所施加血清素的浓度，也取决于细胞暴露于血清素的时间。使用最近描述的基于微量滴定板的生物测定法，评估了一系列血清素受体配体作为黑素细胞血清素受体的激动剂或拮抗剂。药理学特征表明存在一种受体，它与其他先前描述的血清素受体具有一些共同特性，但似乎有所不同。
