Dekens-Konter J A, Knol A, Olsson S, Meyboom R H, de Koning G H
Registratie Evaluatie Bijwerkingen, Apotheek AZG, Groningen.
Ned Tijdschr Geneeskd. 1994 Mar 5;138(10):528-31.
Four cases were reported to the Netherlands Pharmacovigilance Foundation LAREB of Achilles tendinitis, as a suspected adverse reaction to pefloxacin; the patients were two men of 64 years old, one of 33 and one of 76 years old. More than twenty cases of tendinitis have previously been described in the literature in association with pefloxacin and various other fluoroquinolone derivatives; tendon rupture was a frequent complication. In the data base of the WHO Collaborating Centre for International Drug Monitoring tendon disorders are a very rare reaction, with the exception of fluoroquinolone derivatives. More information is needed with regard to the frequency of tendinopathy during the use of pefloxacin and the other drugs in this group. Achilles tendon rupture is an serious condition, often requiring surgical treatment. Patients using a fluoroquinolone derivative should be informed of the risk of developing tendinitis and tendon rupture.
有4例跟腱炎病例报告给了荷兰药物警戒基金会LAREB，怀疑是对培氟沙星的不良反应；患者为两名64岁男性、一名33岁男性和一名76岁男性。此前文献中已描述过20多例与培氟沙星及其他多种氟喹诺酮衍生物相关的肌腱炎病例；肌腱断裂是常见并发症。在世界卫生组织国际药物监测合作中心的数据库中，除氟喹诺酮衍生物外，肌腱疾病是非常罕见的不良反应。关于使用培氟沙星及该组其他药物期间肌腱病的发生频率，还需要更多信息。跟腱断裂是一种严重病症，通常需要手术治疗。应告知使用氟喹诺酮衍生物的患者发生肌腱炎和肌腱断裂的风险。
