Mariatti M, Bordino S, Basile F
Divisione di Ginecologia e Ostetricia, Regione Piemonte, USL n. 3, Ospedale Martini, Torino.
Minerva Ginecol. 1993 Dec;45(12):637-42.
In this paper, starting from a case of neurofibromatosis adversely affecting pregnancy, the authors consider several interactions between pregnancy and Von Recklinhausen's diseases. The review of the literature emphasizes either an exacerbation of the maternal disease because of pregnancy, or the onset appearance of serious complications such as sarcomatous degeneration of neurofibromas, activation of a silent pheochromocytoma, rupture of an aneurysm. Moreover, the effects of neurofibromatosis on the pregnancy cause an elevated risk of IUGR, pregnancy hypertension, abortion and stillbirth and oligohydramnios. The pregnancy of a patient affected with neurofibromatosis needs careful evaluation of the maternal clinical conditions and of the foetus-placenta unity.
在本文中，作者从一例对妊娠产生不利影响的神经纤维瘤病病例入手，探讨了妊娠与冯·雷克林豪森病之间的几种相互作用。文献综述强调，妊娠可能会使母体疾病加重，或者引发严重并发症，如神经纤维瘤肉瘤样变性、隐匿性嗜铬细胞瘤激活、动脉瘤破裂。此外，神经纤维瘤病对妊娠的影响会导致胎儿生长受限、妊娠高血压、流产、死产和羊水过少的风险增加。患有神经纤维瘤病的患者妊娠时，需要仔细评估母体临床状况以及胎儿-胎盘单位情况。
