Ryszka F, Dróźdź M, Dolińska B, Zientarska G, Szulc B
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Katowice, Poland.
Pharmazie. 1994 Jan;49(1):47-8.
The dynamics of selenium concentration changes in blood, organs and tissues of rats after a single intragastric administration of selenium yeast and sodium selenite was determined. The course of selenium concentration changes in blood was described, the pharmacokinetic parameters were estimated according to the trivalent equation of dicompartment model and the selenium content in liver, kidneys, small intestine, spleen, heart, brain, stomach, testicles and prostate was determined 48 h after the administration of selenium preparations.
测定了大鼠单次灌胃给予硒酵母和亚硒酸钠后，血液、器官及组织中硒浓度变化的动态情况。描述了血液中硒浓度的变化过程，根据二室模型的三价方程估算药代动力学参数，并在给予硒制剂48小时后测定肝脏、肾脏、小肠、脾脏、心脏、大脑、胃、睾丸和前列腺中的硒含量。
