Wang X Y, Li L, Han J, Cui G A, Guo J A
Institute of Basic Medical Sciences of Liaoning Province, Shenyang, China.
Zhongguo Yao Li Xue Bao. 1990 Mar;11(2):184-7.
Sodium selenite has been used for prevention and treatment of Keshan disease and Kaschin-Beck's disease. The efficacious dosage regimens of sodium selenite in low-Se human body have not been clear. A single iv or ig of sodium selenite 2.0 mg/kg was given to rabbits. Selenium in whole blood was determined fluorophotomerically. The concentration-time curve following a single iv of sodium selenite in rabbits was found to be of 3-compartment open model. The pharmacokinetic parameters were: T1/2 x 0.11 +/- 0.03 h, T1/2 alpha 6.8 +/- 2.8 h, T1/2 beta 215 +/- 35 h, Vc 0.50 +/- 0.07 L/kg, Cl 19 +/- 5 ml/(kg.h), AUC 146 +/- 26 mg.h/L. The concentration-time curve following a single ig of sodium selenite showed a pattern of 2-compartment open model. The parameters were: T1/2 kappa a 13 +/- 6 h, T1/2 alpha 3.6 +/- 1.9 h, T1/2 beta 338 +/- 107 h, Vc 2.9 +/- 1.3 L/kg, AUC 78 +/- 29 mg.h/L, Cl 27 +/- 11 ml/(kg.h). In low-Se rabbits the distribution in body was more rapid and more extensive, and the bioavailability was higher than that in normal-Se rabbits. Therefore, attention should be paid to the different levels of selenium during therapy with sodium selenite.
亚硒酸钠已用于克山病和大骨节病的防治。亚硒酸钠在低硒人体中的有效给药方案尚不清楚。给家兔静脉注射或灌胃2.0mg/kg亚硒酸钠。用荧光分光光度法测定全血中的硒。发现家兔静脉注射亚硒酸钠后的浓度-时间曲线符合三室开放模型。药代动力学参数为：T1/2x0.11±0.03小时，T1/2α6.8±2.8小时，T1/2β215±35小时，Vc0.50±0.07L/kg，Cl19±5ml/(kg·h)，AUC146±26mg·h/L。家兔灌胃亚硒酸钠后的浓度-时间曲线呈二室开放模型。参数为：T1/2κa13±6小时，T1/2α3.6±1.9小时，T1/2β338±107小时，Vc2.9±1.3L/kg，AUC78±29mg·h/L，Cl27±11ml/(kg·h)。在低硒家兔中，其在体内的分布更快、更广泛，生物利用度高于正常硒家兔。因此，在亚硒酸钠治疗期间应注意不同的硒水平。
