Samani N J, Mauric A T, Nair S, Thompson J, De Bono D P
Department of Cardiology, University of Leicester, UK.
Q J Med. 1994 Jan;87(1):41-8.
We assessed all patients (n = 120) who underwent left ventricular aneurysmectomy as part of a cardiac surgical procedure at the Groby Road Hospital subregional cardiothoracic centre (1980-1990). Of these, 71% had had only one prior myocardial infarction and 84% had symptoms generally associated with aneurysms (congestive cardiac failure, ventricular arrythmias or systemic embolism). The indication for surgery was a combination of angina and aneurysm-related symptoms in 43%, one or more aneurysm-related symptoms in 35%, and angina alone in 22%. The majority of patients (57%) underwent aneurysmectomy and coronary artery bypass grafting, although 35% underwent aneurysmectomy alone. Most (61%) aneurysms were > 6 cm in size, and 75% were located at the apex of the left ventricle. Forty per cent had a mural thrombus, and there was no relationship between prior warfarin use and occurrence of mural thrombus. Overall perioperative mortality was 17% (20 patients), although mortality halved between the first and second halves of the study period. The main reason for perioperative was pump failure. Seventeen patients died late during follow-up (mean 52.5 months), the main cause being further myocardial infarction. Nevertheless, 65% were still alive at 5 years, and 81% and 66% of survivors were still better than pre-operatively at 5 and 8 years, respectively. Post-operative improvement was equally as good in patients who underwent aneurysmectomy alone, or those operated on for aneurysm-related symptoms, as in the whole group. In logistic regression analysis, the only predictor of adverse long-term outcome was the number of previous myocardial infarctions.(ABSTRACT TRUNCATED AT 250 WORDS)
我们评估了在格罗比路医院地区心胸中心(1980 - 1990年)接受左心室动脉瘤切除术作为心脏外科手术一部分的所有患者(n = 120)。其中,71%仅有一次既往心肌梗死,84%有通常与动脉瘤相关的症状(充血性心力衰竭、室性心律失常或系统性栓塞)。手术指征为心绞痛与动脉瘤相关症状合并的占43%,一种或多种动脉瘤相关症状的占35%,仅心绞痛的占22%。大多数患者(57%)接受了动脉瘤切除术和冠状动脉搭桥术,尽管35%仅接受了动脉瘤切除术。大多数(61%)动脉瘤大小>6 cm,75%位于左心室心尖。40%有附壁血栓,既往使用华法林与附壁血栓的发生无关。围手术期总体死亡率为17%(20例患者),尽管在研究期的前半段和后半段死亡率减半。围手术期的主要原因是泵衰竭。17例患者在随访后期死亡(平均52.5个月),主要原因是再次心肌梗死。然而,5年时65%的患者仍存活,存活者在5年和8年时分别有81%和66%的情况仍比术前好。仅接受动脉瘤切除术的患者,或因动脉瘤相关症状接受手术的患者,术后改善情况与整个组一样好。在逻辑回归分析中,长期不良结局的唯一预测因素是既往心肌梗死的次数。(摘要截断于250字)