与死亡博弈：剖析细胞凋亡机制的组成部分

Dicing with death: dissecting the components of the apoptosis machinery.

作者信息

Martin S J, Green D R, Cotter T G

机构信息

Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, CA 92037.

出版信息

Trends Biochem Sci. 1994 Jan;19(1):26-30. doi: 10.1016/0968-0004(94)90170-8.

DOI:10.1016/0968-0004(94)90170-8

PMID:8140617

Abstract

Apoptosis, a mode of cell death commonly observed when death is a desirable or programmed event, has several characteristic structural features. These features appear to be induced by a range of gene products which, together, supervise and participate in the controlled dismantling of the cell. In this article the molecular components of the apoptotic machinery and the proteins implicated in the regulation of this mechanism of cell death are discussed.

摘要

凋亡是一种常见于死亡为理想或程序性事件时的细胞死亡模式，具有若干特征性结构特点。这些特点似乎是由一系列基因产物诱导产生的，这些基因产物共同监督并参与细胞的可控拆解。本文将讨论凋亡机制的分子成分以及与这种细胞死亡机制调控相关的蛋白质。