Takahashi S, Kondo H, Yoshimura M
Folia Psychiatr Neurol Jpn. 1975;29(3):215-20. doi: 10.1111/j.1440-1819.1975.tb02338.x.
Twenty-five depressed patients were examined as to their growth hormone responses to TRH. An enhanced pituitary growth hormone response to intravenous injection of 500 mug TRH was observed in eight depressed patients, while TRH administration did not raise growth hormone levels in nine of 10 normal subjects examined. Occurrence of enhanced response of growth hormone was not related to the thyrotropin values after TRH administration. Bipolar patients exhibited enhanced growth-hormone response more frequently than unipolar patients. Five patients with involutional depression and neurotic depression who showed the most insufficient thyrotropin release to TRH administration together with lowered thyroid function revealed to be non-responders of growth hormone.
对25名抑郁症患者进行了促甲状腺激素释放激素（TRH）对生长激素反应的检查。在8名抑郁症患者中观察到垂体对静脉注射500微克TRH的生长激素反应增强，而在10名接受检查的正常受试者中，有9名在给予TRH后生长激素水平未升高。生长激素反应增强的发生与给予TRH后的促甲状腺激素值无关。双相情感障碍患者比单相情感障碍患者更频繁地表现出生长激素反应增强。5名患有更年期抑郁症和神经症性抑郁症的患者，在给予TRH后促甲状腺激素释放最不足且甲状腺功能降低，结果显示为生长激素无反应者。
