Kishimoto A, Mizukawa R, Matsuzaki F, Hazama H, Kamase H, Tanaka K, Kunimoto N
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan.
Acta Psychiatr Scand. 1994 Jan;89(1):46-51. doi: 10.1111/j.1600-0447.1994.tb01484.x.
The prophylactic effect of mianserin on recurrent depression was studied in a double-blind comparison with an inactive placebo by analyzing the recurrence rate and the number of depressive episodes in 9 mianserin-treated (daily dose 20-60 mg) and 13 placebo-treated patients. The selected patients were those who had a higher incidence of recurrence (more than 2 depressive episodes during the 2 years preceding the study). During the 18-month study period, 4 of 9 mianserin-treated patients and all 13 placebo-treated patients had recurrences. The ratio between patients with recurrence and total patients (recurrence ratio) was lower in the mianserin-treated group throughout the study, and the intergroup difference from the 3rd to the 18th month was significant. In the mianserin-treated group, the frequency of episode recurrence during the study period was significantly lower and the total duration of episodes was significantly shorter than those in the placebo-treated group. The treatments did not differ significantly in safety. These results clearly indicate that mianserin is effective in the prophylaxis of recurrent depressive episodes.
通过分析9名接受米安色林治疗（每日剂量20 - 60毫克）和13名接受安慰剂治疗患者的复发率和抑郁发作次数，在一项与无活性安慰剂的双盲比较中研究了米安色林对复发性抑郁症的预防作用。所选患者为复发率较高（在研究前2年中有超过2次抑郁发作）的患者。在18个月的研究期间，9名接受米安色林治疗的患者中有4名复发，而13名接受安慰剂治疗的患者全部复发。在整个研究过程中，米安色林治疗组复发患者与总患者的比例（复发率）较低，并且从第3个月到第18个月的组间差异具有显著性。在米安色林治疗组中，研究期间发作复发的频率显著低于安慰剂治疗组，发作的总持续时间也显著短于安慰剂治疗组。两种治疗在安全性方面无显著差异。这些结果清楚地表明米安色林对预防复发性抑郁发作有效。
