Onghena P, De Cuyper H, Van Houdenhove B, Verstraeten D
Faculty of Psychology and Education, K.U. Leuven, Belgium.
Acta Psychiatr Scand. 1993 Sep;88(3):198-204. doi: 10.1111/j.1600-0447.1993.tb03439.x.
There is evidence that antidepressants may have an analgesic effect in chronic pain. To replicate this effect and to throw light on the processes involved, a 12-week cross-over double-blind trial of mianserin versus placebo was carried out in 4 diagnostic groups: A) depressive patients without pain complaints (n = 8), B) depressive patients with chronic organic pain (n = 8), C) patients with somatoform pain disorder and vital signs of depression (n = 11) and D) patients with chronic organic pain without depression (n = 8). Although a mianserin-induced antidepressant effect in group A was evident, no significant pain reduction was accomplished in any group. The reasons for this failure to replicate the antidepressant-induced analgesic effect are discussed.
有证据表明，抗抑郁药可能对慢性疼痛具有镇痛作用。为了复制这种效果并阐明其中涉及的过程，在4个诊断组中进行了一项为期12周的米安色林与安慰剂交叉双盲试验：A）无疼痛主诉的抑郁症患者（n = 8），B）患有慢性器质性疼痛的抑郁症患者（n = 8），C）伴有抑郁生命体征的躯体形式疼痛障碍患者（n = 11）和D）无抑郁症的慢性器质性疼痛患者（n = 8）。虽然在A组中米安色林诱导的抗抑郁作用明显，但在任何组中均未实现显著的疼痛减轻。讨论了未能复制抗抑郁药诱导的镇痛作用的原因。
