脂质体包裹的胞壁酰三肽磷脂酰乙醇胺对正常和白细胞减少小鼠肺炎克雷伯菌败血症的治疗
Treatment of Klebsiella pneumoniae septicemia in normal and leukopenic mice by liposome-encapsulated muramyl tripeptide phosphatidylethanolamide.
作者信息
Melissen P M, van Vianen W, Bakker-Woudenberg I A
机构信息
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University, Rotterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1994 Jan;38(1):147-50. doi: 10.1128/AAC.38.1.147.
Abstract
The effect of free muramyl tripeptide phosphatidylethanolamide (MTPPE) and liposome-encapsulated MTPPE (LE-MTPPE) on Klebsiella pneumoniae septicemia resulting from intraperitoneal bacterial inoculation was investigated in mice. When administering a single prophylactic dose at 24 h before bacterial inoculation, the percentage survival was 55% (MTPPE) or 40% (LE-MTPPE), whereas untreated control mice died. Only repeated prophylactic treatment with LE-MTPPE could further increase survival up to 85%.
摘要
在小鼠中研究了游离的胞壁酰三肽磷脂酰乙醇胺（MTPPE）和脂质体包裹的MTPPE（LE-MTPPE）对腹腔细菌接种所致肺炎克雷伯菌败血症的影响。在细菌接种前24小时给予单次预防性剂量时，存活率分别为55%（MTPPE）或40%（LE-MTPPE），而未治疗的对照小鼠死亡。只有用LE-MTPPE进行重复预防性治疗才能将存活率进一步提高到85%。
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