Maria B L, Drane W E, Quisling R G, Ringdahl D M, Mickle J P, Mendenhall N P, Marcus R B, McCollough W M, Hamed L M, Eskin T A
Pediatric Neuro-Oncology Program, University of Florida College of Medicine, Gainesville 32610-0296.
Pediatr Neurosurg. 1994;20(1):11-8. doi: 10.1159/000120760.
Thallium-201 chloride single photon emission computed tomography (201Tl SPECT) has been proposed as a diagnostic tool in the assessment of patients with brain tumors. We performed SPECT scans coupled with magnetic resonance imaging (MRI) in children with brain tumors to determine the sensitivity and potential value of SPECT in neuro-oncology. Each patient was injected with 2.5-3.0 mCi of thallium chloride, followed by technetium-99m HMPAO (5-15 mCi) to assess cerebral perfusion. 201Tl uptake was imaged with triple-headed SPECT in 20/24 (83%) histologically and anatomically diverse neoplasms with MRI-measurable residual disease, including 13/16 (80%) posterior fossa tumors. 201Tl SPECT demonstrated uptake in tumors with MRI volumes ranging from 0.03 to 60 cm3. 201Tl SPECT imaging was not correlated with the following MRI features: gadolinium enhancement, necrosis, exophytic, unicentric and multicentric. 201Tl uptake was not detectable in patients with tumors of maldevelopmental origin or radionecrosis. It is suggested that 201Tl SPECT is an important imaging adjunct in the assessment of children with brain tumors.
氯化铊-201单光子发射计算机断层扫描（201Tl SPECT）已被提议作为评估脑肿瘤患者的一种诊断工具。我们对患有脑肿瘤的儿童进行了SPECT扫描并结合磁共振成像（MRI），以确定SPECT在神经肿瘤学中的敏感性和潜在价值。每位患者静脉注射2.5 - 3.0毫居里的氯化铊，随后注射99m锝标记的六甲基丙二胺肟（5 - 15毫居里）以评估脑灌注情况。在24例经组织学和解剖学分类、MRI可测量残留病灶的不同肿瘤患者中，有20例（83%）通过三头SPECT对201Tl摄取情况进行了成像，其中包括16例后颅窝肿瘤中的13例（80%）。201Tl SPECT显示，MRI体积范围从0.03至60立方厘米的肿瘤均有摄取。201Tl SPECT成像与以下MRI特征无关：钆增强、坏死、外生性、单中心和多中心。在发育异常起源的肿瘤或放射性坏死患者中未检测到201Tl摄取。提示201Tl SPECT是评估儿童脑肿瘤的一种重要的影像辅助手段。
