Hyde J S, Koch D F, Isenberg P D, Werner P
JAMA. 1976 Mar 15;235(11):1125-30.
Serial roentgenograms and technetium Tc 99m macroaggregated albumin lung scans were done simultaneously in 30 bronchodilator-dependent asthmatic children and young adults during both relative remission and attacks of status asthmaticus. When chest roentgenograms showed air trapping and increased peribronchial vascular marking associated with persistent perfusion defects, the children benefited from further laboratory studies and continuous comprehensive therapy. Serial scans provided information about underperfusion that was not discernible either by roentgenograms or by usual blood gas studies. Also, lung scans are easier to obtain in children with long-standing asthma than are detailed pulmonary tests. In our study, technetium Tc 99m macroaggregated albumin scans showed persistent regional perfusion defects in 20 children wiht chronic asthma during relative remission and exacerbations.
对30名依赖支气管扩张剂的哮喘儿童和青年在相对缓解期和哮喘持续状态发作期间同时进行了系列X线胸片检查和锝Tc 99m聚合白蛋白肺扫描。当胸部X线胸片显示气体潴留以及与持续灌注缺损相关的支气管周围血管纹理增粗时，这些儿童从进一步的实验室检查和持续综合治疗中获益。系列扫描提供了X线胸片或常规血气分析无法发现的灌注不足信息。此外，对于长期患哮喘的儿童，肺扫描比详细的肺部检查更容易进行。在我们的研究中，锝Tc 99m聚合白蛋白扫描显示，20名慢性哮喘儿童在相对缓解期和病情加重期存在持续性局部灌注缺损。
