Kleineidam M, Guthoff R
Institut für Biophysik und Radiobiologie, Universitäts-Klinik Hamburg-Eppendorf, Germany.
Ger J Ophthalmol. 1994 Jan;3(1):22-5; discussion 25-6.
We reviewed 184 cases of uveal melanoma treated with 106Ru eye plaques. The influences of the dose rate, the total dose and the initial tumour size on the incidence of metastases were of major interest in this retrospective analysis. It is widely accepted that the risk of metastatic spread increases with increasing tumour volume. However, for tumours measuring < 10 mm in basal diameter the dose rate in brachytherapy with 106Ru eye plaques might be important, since we observed a better prognosis for patients treated with plaques of relatively low activity.
我们回顾了184例接受106钌眼敷贴器治疗的葡萄膜黑色素瘤病例。在这项回顾性分析中，剂量率、总剂量和初始肿瘤大小对转移发生率的影响是主要关注的问题。人们普遍认为，转移扩散的风险会随着肿瘤体积的增加而增加。然而，对于基底直径<10mm的肿瘤，使用106钌眼敷贴器进行近距离放射治疗时的剂量率可能很重要，因为我们观察到使用活性相对较低的敷贴器治疗的患者预后较好。
