Hruby D E, Franke C A
Dept of Microbiology, Oregon State University, Corvallis 97331-3804.
Trends Microbiol. 1993 Apr;1(1):20-5. doi: 10.1016/0966-842x(93)90020-r.
Viruses take advantage of the host's protein modification and targeting pathways to modify their own proteins and to ensure that they assume active configurations and locate appropriately for assembly. In many viruses, one recurrent theme in such processes is exploitation of cellular protein acylation pathways for the addition of myristic and palmitic acid to capsid or envelope proteins.
病毒利用宿主的蛋白质修饰和靶向途径来修饰自身蛋白质,以确保它们呈现活性构象并在合适的位置进行组装。在许多病毒中,此类过程的一个反复出现的主题是利用细胞蛋白质酰化途径,将肉豆蔻酸和棕榈酸添加到衣壳蛋白或包膜蛋白上。