McLean A R
Zoology Dept, University of Oxford, UK.
Trends Microbiol. 1993 Apr;1(1):9-13. doi: 10.1016/0966-842x(93)90018-m.
There are several theories of the pathogenesis of HIV that attempt to explain the long and variable delay between infection and disease. Here, each theory is reviewed within the context of a simple mathematical model of the interactions between HIV and the immune system. From this model, a theoretical index of progression has been derived that combines elements from each proposed mechanism.
关于HIV发病机制有几种理论,这些理论试图解释从感染到发病之间漫长且多变的延迟。在此,我们将在一个关于HIV与免疫系统相互作用的简单数学模型背景下对每种理论进行综述。从这个模型中,已经推导出一个理论进展指数,该指数整合了每种提出的机制中的要素。