蛋白酶依赖性病毒嗜性与致病性。
Protease-dependent virus tropism and pathogenicity.
作者信息
Nagai Y
机构信息
Dept of Viral Infection, University of Tokyo, Japan.
出版信息
Trends Microbiol. 1993 Jun;1(3):81-7. doi: 10.1016/0966-842x(93)90112-5.
Abstract
Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.
摘要
在易感宿主中，病毒的组织嗜性通常由病毒与受体的相互作用决定。然而，利用相同受体分子的密切相关病毒在嗜性上可能表现出显著差异，或者一种病毒尽管受体广泛存在，却能引起局部感染。现在，这些现象可以通过另一种嗜性机制来解释，即宿主蛋白酶通过激活病毒融合糖蛋白发挥主要作用。
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本文引用的文献
1
Mutational changes of the protease susceptibility of glycoprotein F of Newcastle disease virus: effects on pathogenicity.
J Gen Virol. 1980 Sep;50(1):135-47. doi: 10.1099/0022-1317-50-1-135.
2
The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketone.精氨酸氯甲基酮肽对凝血因子Xa的选择性亲和标记
Thromb Res. 1981;22(5-6):645-52. doi: 10.1016/0049-3848(81)90062-1.
3
Proteolytic cleavage of influenza virus hemagglutinins: primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of Avian influenza viruses.流感病毒血凝素的蛋白水解切割：HA1和HA2之间连接肽的一级结构决定禽流感病毒的蛋白水解切割能力和致病性。
Virology. 1981 Sep;113(2):725-35. doi: 10.1016/0042-6822(81)90201-4.
4
The carboxyterminus of the hemagglutinin-neuraminidase of Newcastle disease virus is exposed at the surface of the viral envelope.新城疫病毒血凝素神经氨酸酶的羧基末端暴露于病毒包膜表面。
Virus Res. 1984;1(5):415-26. doi: 10.1016/0168-1702(84)90027-3.
5
Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?H5N2流感病毒对鸡的毒力是否与血凝素中碳水化合物的缺失有关？
Virology. 1984 Dec;139(2):303-16. doi: 10.1016/0042-6822(84)90376-3.
6
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor.用于加工酵母前体α因子所需的赖氨酸-精氨酸裂解内肽酶的假定结构基因的分离。
Cell. 1984 Jul;37(3):1075-89. doi: 10.1016/0092-8674(84)90442-2.
7
Evidence of proteolytic activation of Sendai virus in mouse lung.仙台病毒在小鼠肺中发生蛋白水解激活的证据。
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8
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9
Trypsin action on the growth of Sendai virus in tissue culture cells. V. An activating enzyme for Sendai virus in the chorioallantoic fluid of the embryonated chicken egg.
Microbiol Immunol. 1980;24(2):113-22. doi: 10.1111/j.1348-0421.1980.tb00569.x.
10
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