蛋白酶依赖性病毒嗜性与致病性。
Protease-dependent virus tropism and pathogenicity.
作者信息
Nagai Y
机构信息
Dept of Viral Infection, University of Tokyo, Japan.
出版信息
Trends Microbiol. 1993 Jun;1(3):81-7. doi: 10.1016/0966-842x(93)90112-5.
Abstract
Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.
摘要
在易感宿主中，病毒的组织嗜性通常由病毒与受体的相互作用决定。然而，利用相同受体分子的密切相关病毒在嗜性上可能表现出显著差异，或者一种病毒尽管受体广泛存在，却能引起局部感染。现在，这些现象可以通过另一种嗜性机制来解释，即宿主蛋白酶通过激活病毒融合糖蛋白发挥主要作用。
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