控制病毒致病性的宿主细胞蛋白酶。
Host cell proteases controlling virus pathogenicity.
作者信息
Klenk H D, Garten W
机构信息
Institut für Virologie, Philipps-Universität Marburg, Germany.
出版信息
Trends Microbiol. 1994 Feb;2(2):39-43. doi: 10.1016/0966-842x(94)90123-6.
PMID:8162439
Abstract
The majority of viral glycoproteins that undergo post-translational proteolysis are cleaved by ubiquitous intracellular proteases; however, a minority are cleaved by secreted proteases available only in a few host systems. The interplay of viral glycoproteins and cellular proteases may have a pivotal role in the spread of infection, host range and pathogenicity.
摘要
大多数经过翻译后蛋白水解的病毒糖蛋白是由普遍存在的细胞内蛋白酶切割的；然而，少数是由仅在少数宿主系统中存在的分泌型蛋白酶切割的。病毒糖蛋白与细胞蛋白酶的相互作用可能在感染传播、宿主范围和致病性方面起关键作用。
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