Perl A, Banki K
Dept of Medicine, State University of New York, Health Science Center, Syracuse 13210.
Trends Microbiol. 1993 Jul;1(4):153-6. doi: 10.1016/0966-842x(93)90131-a.
The human genome contains a complex variety of inherited endogenous retroviral sequences (ERSs), several of which are transcriptionally active and contain open reading frames. Aberrant expression of ERSs and generation of antibodies to ERS-encoded proteins have recently been revealed in autoimmune disorders. Involvement of ERSs could explain both the familial aggregation and the detection of antiretroviral antibodies in autoimmune diseases.
人类基因组包含多种复杂的遗传性内源性逆转录病毒序列（ERSs），其中一些具有转录活性并含有开放阅读框。最近在自身免疫性疾病中发现了ERSs的异常表达以及针对ERS编码蛋白产生的抗体。ERSs的参与可以解释自身免疫性疾病中的家族聚集现象以及抗逆转录病毒抗体的检测结果。
