Yang H M
Burn Unit, Postgraduate Medical College.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1993 Sep;9(5):359-62, 397-8.
Sixty seven burn patients (TBSA > 30%) were entered in a prospective study. Among them, twenty seven experienced delayed fluid resuscitation (DFR group) and the rest had early resuscitation (non-DFR group). Oxygen free radical (OFR) content in the blood was measured with ESR technic, and levels of blood SOD, blood GSHpx, serum MDA were also determined. The results showed: 1 The morbidity and mortality of burn shock and MSOF were higher in DFR group as compared with non-DFR group. 2 There was a significant increase of blood OFR content subsequent to resuscitation in DFR group as compared with that in non-DFR group. 3 The level of MDA in the serum of patients with burn shock was higher in DFR group than that in non-DFR group. 4 In DFR group, the level of serum MDA is higher in patients who developed MSOF as compared with that in patients who did not develop MSOF. The data indicated that DFR augmented the morbidity and mortality of burn shock and MSOF, in which OFR might play a role.
67例烧伤面积大于30%的患者进入一项前瞻性研究。其中，27例经历了延迟液体复苏（DFR组），其余患者进行了早期复苏（非DFR组）。采用ESR技术测定血液中氧自由基（OFR）含量，并测定血超氧化物歧化酶（SOD）、血谷胱甘肽过氧化物酶（GSHpx）、血清丙二醛（MDA）水平。结果显示：1. DFR组烧伤休克和多器官功能障碍综合征（MSOF）的发病率和死亡率高于非DFR组。2. 与非DFR组相比，DFR组复苏后血液OFR含量显著增加。3. DFR组烧伤休克患者血清MDA水平高于非DFR组。4. 在DFR组中，发生MSOF的患者血清MDA水平高于未发生MSOF的患者。数据表明，延迟液体复苏增加了烧伤休克和MSOF的发病率和死亡率，其中氧自由基可能起作用。
