Herath S E, Stalboerger P G, Dahl R J, Parisi J E, Jenkins R B
Section of Laboratory Genetics, Mayo Clinic, Rochester, MN 55905.
Cancer Genet Cytogenet. 1994 Feb;72(2):137-40. doi: 10.1016/0165-4608(94)90129-5.
We report cytogenetic studies on four hemangiopericytomas using in situ culture and robotic harvesting. Simple clonal chromosome abnormalities were observed in each of the three successful tumors. A cerebral tumor had a nonconstitutional 46,XX,t(7;12)(p15;q15) karyotype. A recurrent cerebral tumor had two cell lines: one with a 46,XY,t(2;12)(p13;q24.1) karyotype and one with a 46,XY,t(5;7)(q13;p15) karyotype. Each of the metaphases from a lung tumor had a 46,Y,inv(X)(p22.3q13) karyotype. We conclude that simple nonconstitutional balanced chromosome anomalies of 7p15 and 12q are common in cerebral hemangiopericytomas. It is possible that balanced anomalies of these chromosome regions are related to the pathogenesis of this tumor type.
我们报告了对4例血管外皮细胞瘤进行的细胞遗传学研究，采用原位培养和机器人收获技术。在3例成功的肿瘤中均观察到简单的克隆性染色体异常。1例脑肿瘤具有非先天性的46,XX,t(7;12)(p15;q15)核型。1例复发性脑肿瘤有两个细胞系：一个具有46,XY,t(2;12)(p13;q24.1)核型，另一个具有46,XY,t(5;7)(q13;p15)核型。1例肺肿瘤的每个中期相均具有46,Y,inv(X)(p22.3q13)核型。我们得出结论，7p15和12q的简单非先天性平衡染色体异常在脑血管外皮细胞瘤中很常见。这些染色体区域的平衡异常可能与该肿瘤类型的发病机制有关。
