Jin Y, Jin C, Mertens F, Persson B, Jonsson N
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1998 Apr 15;102(2):100-3. doi: 10.1016/s0165-4608(97)00347-6.
We have cytogenetically and by fluorescence in situ hybridization (FISH) analyzed short-term cultures from a malignant eccrine poroma, a type of tumor in which chromosomal abnormalities have previously not been reported. Combining the results from G-banding and FISH, the karyotype was interpreted as 50,XX,t(3;11;12)(q21;p15;q15),+5,+7,+9, +9,t(12;22)(q13;q13),+del(12)(q15),der(15)t(3;15) (q23;p13),der(17)t(8;17)(q22;p13),-20,add(22)(q13).
我们通过细胞遗传学和荧光原位杂交（FISH）技术分析了恶性小汗腺汗孔瘤的短期培养物，此前尚未有关于该肿瘤染色体异常的报道。结合G显带和FISH的结果，核型被解释为50,XX,t(3;11;12)(q21;p15;q15),+5,+7,+9, +9,t(12;22)(q13;q13),+del(12)(q15),der(15)t(3;15) (q23;p13),der(17)t(8;17)(q22;p13),-20,add(22)(q13) 。
