朗格汉斯细胞组织细胞增生症患儿血细胞中的乳酸脱氢酶同工酶谱

Lactate dehydrogenase isoenzyme patterns in blood cells from histiocytosis X children.

作者信息

Perlino E, Marra E, Maenza S, de Terlizzi M, Coppola B C, Santostasi T, Quagliariello E

机构信息

Centro di Studio sui Mitocondri e Metabolismo Energetico, C.N.R., Bari, Italy.

出版信息

Clin Chim Acta. 1993 Dec 31;223(1-2):83-91. doi: 10.1016/0009-8981(93)90064-b.

DOI:10.1016/0009-8981(93)90064-b

PMID:8143371

Abstract

To find a clinical assay for histiocytosis X (HX) diagnosis, measurements were made of both activity and isoenzyme distribution of lactate dehydrogenase (LDH; EC 1.1.1.27) from the blood cells of 6 acute phase and 9 remission patients. A significant increase in the LDH activity measured in the monocytes and lymphocytes isolated from the blood of the acute phase patients was found. The increased activity was due to an enhancement of the normal pattern of LDH isoenzymes in these cells and not to a change in isoenzyme distribution. No increase was found in monocyte LDH isoenzymes from the patients in remission.

摘要

为找到一种用于组织细胞增多症X（HX）诊断的临床检测方法，对6例急性期患者和9例缓解期患者血细胞中的乳酸脱氢酶（LDH；EC 1.1.1.27）活性及同工酶分布进行了测定。结果发现，急性期患者血液中分离出的单核细胞和淋巴细胞中的LDH活性显著增加。活性增加是由于这些细胞中LDH同工酶的正常模式增强，而非同工酶分布发生变化。缓解期患者的单核细胞LDH同工酶未发现增加。