Coêlho H L, Teixeira A C, Cruz M de F, Gonzaga S L, Arrais P S, Luchini L, La Vecchia C, Tognoni G
Department of Pharmacy, Federal University of Ceará, Fortaleza, Brazil.
Contraception. 1994 Feb;49(2):101-10. doi: 10.1016/0010-7824(94)90084-1.
Misoprostol is used by women in Brazil in case of unwanted pregnancy to attempt abortion. This paper reports the characteristics, pattern of misoprostol use and opinions of a group of 102 women (median age 25 years, range 16-49 years), from Fortaleza, capital of Ceará state, who had used misoprostol to attempt abortion. Seventy-five percent were women of lower social class, 58% had less than 8 years of education and 46% were never married. Misoprostol was used for the first induced abortion by 65 women. Modal dose was 4 tablets--200 micrograms of misoprostol each--most frequently 2 tablets by oral route and 2 tablets by intravaginal route. This pattern of use was associated with the highest rate of abortion, mainly at 9-12 weeks of amenorrhea. Fifty-five percent of women had no pregnancy test; 41% had 8 weeks or less of amenorrhea. Curettage was performed in 49 of 84 women who reported abortion and in 41 of 43 women who entered the hospital. Infection and uterine perforation were the complications described. Seventy-two percent of women were in favor of legalization of abortion, but 52% were also in favor of the prohibition of misoprostol sales; 66% would not repeat misoprostol use and 53% would not suggest it to a friend. The poorest women were less favorable to misoprostol ban. Despite the current lack of safer alternatives, misoprostol does not seem a satisfactory solution to illegal abortion in Brazil.
在巴西，米索前列醇被女性用于意外怀孕时尝试堕胎。本文报告了来自塞阿拉州首府福塔莱萨的102名女性（年龄中位数25岁，范围16 - 49岁）使用米索前列醇尝试堕胎的特征、使用模式及看法。75%为社会阶层较低的女性，58%受教育年限不足8年，46%从未结婚。65名女性首次使用米索前列醇进行人工流产。常用剂量为4片——每片含200微克米索前列醇——最常见的是口服2片和阴道给药2片。这种使用模式与最高的堕胎率相关，主要发生在闭经9 - 12周时。55%的女性未进行妊娠试验；41%闭经8周或更短时间。84名报告堕胎的女性中有49名进行了刮宫术，入院的43名女性中有41名进行了刮宫术。所描述的并发症有感染和子宫穿孔。72%的女性赞成堕胎合法化，但52%也赞成禁止销售米索前列醇；66%不会再次使用米索前列醇，53%不会向朋友推荐。最贫困的女性对禁止米索前列醇的态度不太支持。尽管目前缺乏更安全的替代方法，但在巴西，米索前列醇似乎并不是非法堕胎的令人满意的解决方案。
