Schumann J, Grabs V
Langenbecks Arch Chir. 1975 Sep 10;338(4):251-63. doi: 10.1007/BF01261715.
Observation of 39 patients who had undergone surgery for hyperthyroidism with or without endocrine ophthalmopathy between 1965 and 1972 indicate that this type of therapy involves no higher risk than do medication of radiological measures as far as the course of ophthalmic changes is concerned. Examination of the basal and the TRH-stimulated TSH concentrations i.s. argues against any primarily pituitary cause for progressive ophthalmopathy after surgery. In addition, it elucidates the almost inevitable postoperative development of preclinical hypothyroidism while the clinical condition is still euthyroid, and indicates the necessity of constant postoperative hormone substitution.
对1965年至1972年间接受过甲亢手术（无论有无内分泌性眼病）的39例患者的观察表明，就眼部变化的病程而言，这种治疗方式并不比药物治疗或放射治疗风险更高。对基础促甲状腺激素（TSH）浓度和促甲状腺激素释放激素（TRH）刺激后的TSH浓度的检测表明，不存在任何主要由垂体导致的术后进行性眼病的病因。此外，它阐明了在临床状态仍为甲状腺功能正常时，术后几乎不可避免地会出现亚临床甲状腺功能减退，并表明术后持续进行激素替代的必要性。
