Reddy B S, Simi B, Engle A
Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, New York.
Gastroenterology. 1994 Apr;106(4):883-9. doi: 10.1016/0016-5085(94)90746-3.
BACKGROUND/AIMS: In view of the potential significance of dietary fat and fiber in colon cancer and the possible indirect involvement of diacylglycerols (DAGs) in the pathogenesis of colon cancer, the effect of types of dietary fiber on fecal DAG in premenopausal women was investigated.
Forty-eight women consuming a typical western diet provided two 24-hour stool specimens and two sets of preintervention 4-day food records. They were randomly assigned to one of the fiber groups, namely, a wheat, oat, or corn bran supplement. They consumed their control diet plus 13-15 g of dietary fiber from each source for 8 weeks. At the end of the fiber period, each subject provided two 24-hour stool specimens and 4-day food records. Stool samples collected during the two periods were analyzed for total fat and DAG fatty acids.
All sources of dietary fiber increased the amount of fecal fat excreted. Dietary wheat bran decreased the concentrations of total DAG and DAG containing lauric acid, myristic acid, palmitic acid, stearic acid, and linoleic acid, whereas oat bran increased the DAG composed of oleic acid and linoleic acid compared with the control diet. Corn bran decreased the DAG containing stearic acid.
These results show that the modifying effect of dietary fiber on DAG depends on the type of fiber consumed.
背景/目的：鉴于膳食脂肪和纤维在结肠癌中的潜在重要性，以及二酰基甘油（DAGs）可能间接参与结肠癌的发病机制，本研究调查了膳食纤维类型对绝经前女性粪便DAG的影响。
48名食用典型西方饮食的女性提供了两份24小时粪便样本和两组干预前4天的食物记录。她们被随机分配到其中一个纤维组，即补充小麦、燕麦或玉米麸。她们在对照饮食的基础上，每天从每种来源摄入13 - 15克膳食纤维，持续8周。在纤维摄入期结束时，每位受试者提供两份24小时粪便样本和4天的食物记录。对两个时期收集的粪便样本进行总脂肪和DAG脂肪酸分析。
所有膳食纤维来源均增加了粪便脂肪排泄量。与对照饮食相比，小麦麸降低了总DAG以及含有月桂酸、肉豆蔻酸、棕榈酸、硬脂酸和亚油酸的DAG的浓度，而燕麦麸增加了由油酸和亚油酸组成的DAG。玉米麸降低了含有硬脂酸的DAG。
这些结果表明，膳食纤维对DAG的调节作用取决于所摄入纤维的类型。
