小鼠谷氨酰胺：6-磷酸果糖酰胺转移酶编码cDNA序列。
The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence.
作者信息
Sayeski P P, Paterson A J, Kudlow J E
机构信息
Department of Medicine, University of Alabama at Birmingham 35294.
出版信息
Gene. 1994 Mar 25;140(2):289-90. doi: 10.1016/0378-1119(94)90560-6.
PMID:8144040
Abstract
Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme in hexosamine synthesis and has been implicated in the control of growth factor gene expression. We cloned a mouse cDNA which is 91% homologous to the human sequence. The deduced amino-acid sequence shows 98.6% identity to human GFAT. The cDNA is derived from a 7-kb mRNA in the mouse, while there are multiple-sized human mRNAs.
摘要
谷氨酰胺
果糖-6-磷酸酰胺转移酶（GFAT）是己糖胺合成中的限速酶，并且与生长因子基因表达的调控有关。我们克隆了一个与人类序列有91%同源性的小鼠cDNA。推导的氨基酸序列与人类GFAT有98.6%的同一性。该cDNA源自小鼠中的一个7kb mRNA，而人类有多种大小的mRNA。
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