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用于生物结构研究的三维计算机建模系统。

Three-dimensional computer modelling system for the study of biological structures.

作者信息

Perkins W J, Hashmi S, Jordan M

机构信息

National Institute for Biological Standards & Control, South Mimms, Potters Bar, Herts, UK.

出版信息

Med Biol Eng Comput. 1993 Nov;31(6):557-61. doi: 10.1007/BF02441801.

DOI:10.1007/BF02441801
PMID:8145579
Abstract

A three-dimensional computer modelling system has been developed for use in biology, and is currently running on a Sun3 computer. The data originate as a series of two-dimensional micrographs which are digitised via a TV camera. The two-dimensional images are used to select features of interest and to construct a three-dimensional model. This model can be viewed in vector or solid format, it can be rotated about three orthogonal axes and can be viewed in three dimensions as a stereo pair or an anaglyph. The system has been used in a large number of projects over the past 10-15 years, for example, to examine physiological and nerve structures. The time-consuming part of the process is the selection of features, which involves a high level of biological expertise. Present developments are concerned with reduction of the time spent in feature recognition and involve the introduction of expert systems together with human-computer interaction to deal with problems of identification.

摘要

已开发出一种用于生物学的三维计算机建模系统,目前在Sun3计算机上运行。数据源自一系列通过电视摄像机数字化的二维显微照片。二维图像用于选择感兴趣的特征并构建三维模型。该模型可以以矢量或实体格式查看,可以绕三个正交轴旋转,并且可以作为立体对或互补色立体图以三维方式查看。在过去10到15年中,该系统已用于大量项目,例如检查生理和神经结构。该过程中耗时的部分是特征选择,这需要高水平的生物学专业知识。目前的进展涉及减少特征识别所花费的时间,并涉及引入专家系统以及人机交互来处理识别问题。

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本文引用的文献

1
Three-dimensional reconstruction of biological sections.
J Biomed Eng. 1982 Jan;4(1):37-43. doi: 10.1016/0141-5425(82)90024-3.
2
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo.原癌基因int-1的表达仅限于发育中的小鼠胚胎中的特定神经细胞。
Cell. 1987 Jul 3;50(1):79-88. doi: 10.1016/0092-8674(87)90664-7.
3
Human-computer interaction and expert systems for three-dimensional studies of biomedical images.用于生物医学图像三维研究的人机交互与专家系统。
Med Inform (Lond). 1989 Apr-Jun;14(2):135-47. doi: 10.3109/14639238908994986.
4
The transfer of selected image data to a computer using a conductive tablet.使用导电数位板将选定的图像数据传输到计算机。
J Biomed Eng. 1979 Oct;1(4):240-6. doi: 10.1016/0141-5425(79)90158-4.