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[微生物源抑制剂对不同α-葡萄糖苷酶作用的比较研究]

[A comparative study of the effect of inhibitors of microbial origin on different alpha-glucosidases].

作者信息

Akulova N Iu, Kazanina G A, Selezneva A A

出版信息

Prikl Biokhim Mikrobiol. 1994 Jan-Feb;30(1):83-7.

PMID:8146113
Abstract

The action of a new alpha-glucosidase inhibitor from Streptomyces sp. and Acarbose on alpha-glucosidases of various origins has been studied. Differences in specificity, efficiency, nature and type of inhibition of microbial glucosidases and some enzymes of the small intestine mucosa by the biologically active substances studied were revealed. At certain concentrations these inhibitors can be substrates for some intestinal glucosidases. It is suggested that the inhibitor from Streptomyces sp. (in combination with a diet) can be used for regulation of some disturbances in carbohydrate metabolism.

摘要

对来自链霉菌属的一种新型α-葡萄糖苷酶抑制剂和阿卡波糖作用于不同来源的α-葡萄糖苷酶进行了研究。揭示了所研究的生物活性物质对微生物糖苷酶和小肠黏膜某些酶在特异性、效率、抑制性质和类型方面的差异。在一定浓度下,这些抑制剂可作为某些肠道糖苷酶的底物。有人提出,来自链霉菌属的抑制剂(与饮食相结合)可用于调节碳水化合物代谢中的某些紊乱。

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