神经降压素兴奋基底前脑胆碱能神经元：离子及信号转导机制。
Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms.
作者信息
Farkas R H, Nakajima S, Nakajima Y
机构信息
Department of Anatomy and Cell Biology, University of Illinois, College of Medicine at Chicago 60612.
出版信息
Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2853-7. doi: 10.1073/pnas.91.7.2853.
The whole-cell patch-clamp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxin-insensitive G protein.
采用全细胞膜片钳技术研究神经降压素对从大鼠Meynert基底核培养的胆碱能神经元的作用。神经降压素通过诱导至少部分由Na⁺携带的初始内向电流并降低内向整流钾电导来兴奋神经元。内向整流钾电导的降低由百日咳毒素不敏感的G蛋白介导。
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