Grant K I, Marais M P, Dhansay M A
National Research Programme for Nutritional Intervention, South African Medical Research Council, Tygerberg.
Am J Clin Nutr. 1994 Apr;59(4):853-60. doi: 10.1093/ajcn/59.4.853.
Nineteen young male normolipidemic volunteers sequentially consumed three test meals consisting of cream only, sucrose only, or cream with sucrose. These oral fat-tolerance tests showed an amplification of the postprandial excursion of serum triglyceride and cholesterol concentrations when sucrose was included in a lipid-rich meal compared with both the cream-only meal and the sucrose-only meal. The triglyceride concentration increase occurred only in the late postprandial phase whereas the cholesterol concentration was increased for the entire 8 h studied. The increased triglyceride and cholesterol concentrations in the triglyceride-rich lipoprotein (TRL) fraction accounted for most of the increase. The clearance of an intravenous lipid emulsion was measured before and 2 and 4 h after a sucrose meal. The two postprandial clearance rates were 34% slower than the fasting value. These data indicate that sucrose-induced postprandial hypertriglyceridemia may be induced by an inhibition of the clearance of triglyceride. The slower rate of lipolysis may cause the accumulation of cholesterol in TRL.
19名血脂正常的年轻男性志愿者依次食用了三份试验餐，分别仅含奶油、仅含蔗糖或含奶油与蔗糖。这些口服脂肪耐量试验表明，与仅含奶油的餐食和仅含蔗糖的餐食相比，当富含脂质的餐食中含有蔗糖时，餐后血清甘油三酯和胆固醇浓度的波动会增大。甘油三酯浓度仅在餐后后期升高，而胆固醇浓度在整个8小时的研究期间都升高。富含甘油三酯的脂蛋白（TRL）部分中甘油三酯和胆固醇浓度的升高占了大部分升高幅度。在蔗糖餐之前以及餐后2小时和4小时测量了静脉注射脂质乳剂的清除率。餐后两个时间点的清除率比空腹值慢34%。这些数据表明，蔗糖诱导的餐后高甘油三酯血症可能是由甘油三酯清除率的抑制所引起。脂肪分解速率减慢可能导致胆固醇在TRL中积累。
