Lauwerys R R, Buchet J P, Andrien F
Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium.
Am J Ind Med. 1994 Feb;25(2):297-300. doi: 10.1002/ajim.4700250216.
In male subjects not occupationally exposed to benzene, the concentration of muconic acid (MA) in urine is usually below 0.5 mg/g creatinine. At ambient levels of benzene exposure (below 0.01 ppm), the mean MA level was greater in 21 smokers than in 14 nonsmokers. In 38 male subjects employed in garages and coke ovens, a statistically significant correlation was found between the airborne concentration of benzene measured with passive monitors and MA in postshift urine. The mean postshift MA concentrations corresponding to a benzene 8-hour time-weighted average exposure (TWA) of 0.5 and 1 ppm were 0.8 and 1.4 mg/g creatinine, respectively.
在未职业接触苯的男性受试者中，尿中粘康酸（MA）浓度通常低于0.5mg/g肌酐。在苯环境暴露水平（低于0.01ppm）下，21名吸烟者的MA平均水平高于14名不吸烟者。在38名受雇于车库和炼焦炉的男性受试者中，用被动监测器测得的空气中苯浓度与下班后尿液中的MA之间存在统计学显著相关性。苯8小时时间加权平均暴露（TWA）为0.5和1ppm时，相应的下班后MA平均浓度分别为0.8和1.4mg/g肌酐。
