Savenko S N, Vladkovskiĭ I K, Maĭdanik F E
Zh Nevropatol Psikhiatr Im S S Korsakova. 1975;75(8):1162-7.
The authors conducted a study of the histamine system (H), diaminoxidase (DO), histaminopexic index (HPI) using the biological method in 127 patients with hypertensive disease and cerebral atherosclerosis with brain circulation disturbances and in 23 patients with atherosclerotic parkinsonism. It was displayed that in the majority of the patients the H level and HPI value were pathologically changed, but DO activity was disturbed to a lesser degree. The authors demonstrated some correlations between the fluctuations of H-DO-HPI system and the character of the brain circulation disturbances, the period of the stroke, severity of the disease and an etiological factor. According to the authors' opinion changes in H-DO-HPI system were in a direct correlation with fluctuations of the level in the biological fluids of catecholimes, serotonin, acetylcholine, glucocorticoids. Recommendations concerning a discontinuation of histaminemia or its negative effects were given.
作者采用生物学方法对127例患有高血压病、脑动脉硬化伴脑循环障碍的患者以及23例患有动脉粥样硬化性帕金森病的患者的组胺系统（H）、二胺氧化酶（DO）、组胺固定指数（HPI）进行了研究。结果显示，大多数患者的H水平和HPI值发生了病理性改变，但DO活性受到的干扰程度较小。作者证明了H-DO-HPI系统的波动与脑循环障碍的特征、中风时期、疾病严重程度和病因之间存在一些相关性。作者认为，H-DO-HPI系统的变化与儿茶酚胺、血清素、乙酰胆碱、糖皮质激素等生物体液中水平的波动直接相关。并给出了关于终止组胺血症或其负面影响的建议。
