Tobler I, Franken P, Gao B, Jaggi K, Borbély A A
Institute of Pharmacology, University of Zürich, Switzerland.
Arch Ital Biol. 1994 Jan;132(1):39-52.
To investigate the relationship between thermoregulation and sleep regulation, rats were sleep-deprived for 3 hours at two different ambient temperatures. Sleep deprivations (SD) were performed at 23 degrees C (SD-23) and at 32 degrees C (SD-32) in the beginning of the 12-h light period in animals chronically implanted with ECoG and EMG electrodes, and with epidural and hypothalamic thermistors. SD-32 enhanced cerebral temperature more than SD-23 at both brain sites. The SD-induced hyperthermia was followed by a fall of brain temperature below baseline. During recovery from either SD procedure, waking was reduced and sleep continuity increased. REM sleep was increased after SD-32. EEG slow-wave activity (spectral power density in the 0.75-4.0 Hz band) exceeded the baseline level in the first 3-h interval of recovery; however, the effects of SD-23 and SD-32 did not differ. In the same time interval, power density in the 1.25-1.5 Hz bin as well as in some bins in the theta and alpha band was higher after SD-32 than after SD-23. The increase in hypothalamic temperature during SD did not correlate with the increase in SWA during recovery. It is concluded that even a brief SD has major repercussions on recovery sleep whereas the extent of cerebral hyperthermia during SD is only a minor factor.
为了研究体温调节与睡眠调节之间的关系，在两种不同的环境温度下对大鼠进行3小时的睡眠剥夺。在长期植入脑电图（ECoG）和肌电图（EMG）电极以及硬膜外和下丘脑热敏电阻的动物中，于12小时光照期开始时在23摄氏度（SD - 23）和32摄氏度（SD - 32）进行睡眠剥夺。在两个脑区，SD - 32引起的脑温升高均超过SD - 23。SD诱导的体温过高之后，脑温会降至基线以下。在从任何一种SD程序恢复期间，清醒时间减少，睡眠连续性增加。SD - 32后快速眼动（REM）睡眠增加。脑电图慢波活动（0.75 - 4.0赫兹频段的频谱功率密度）在恢复的前3小时内超过基线水平；然而，SD - 23和SD - 32的影响没有差异。在同一时间间隔内，SD - 32后的1.25 - 1.5赫兹频段以及θ和α频段某些频段的功率密度高于SD - 23。SD期间下丘脑温度的升高与恢复期间慢波活动（SWA）的增加不相关。结论是，即使是短暂的SD对恢复性睡眠也有重大影响，而SD期间脑热过高的程度只是一个次要因素。
